Best NAD+ Supplement Brands in the test 2024 – Reviews, Benefits, Price, Side effects, Where to buy NAD+ Supplements?

What is NAD+?

Nicotinamide mononucleotide is a naturally occurring compound found in all living organisms. It acts as a direct precursor to an essential molecule, nicotinamide adenine dinucleotide, and plays a key role in increasing NAD+ levels in cells. It is an important coenzyme that enhances the effectiveness of this supplements and is involved in a wide range of metabolic activities. As people age, there is a natural decline in NAD+ levels, which affects muscle function, immune system performance and weight management.

NAD+ are substances that contribute to the production of other compounds. These precursors undergo various chemical reactions in the body and are eventually converted. Importantly, precursors can be divided into five main types: tryptophan, nicotinic acid (NA), nicotinamide (NAM), nicotinamide riboside (NR) and NAD+.

Basically, NAD+ is an enzyme-produced nucleotide that is essential for the body’s metabolism and energy production. In addition, taking this supplements offers anti-aging benefits, including promoting longevity, reducing age-related weight gain, improving insulin sensitivity, and improving brain and heart health.

How does NAD+ work?

Research has shown that NAD+ has a significant effect on the ageing process by restoring a balanced energy state in the body’s systems. This effect is due to its ability to increase production in cells, which is essential for energy metabolism.

NAD+ helps to improve mitochondrial efficiency and reduce oxidative stress, both of which are key factors in ageing. As a result, supplements containing NAD+ have been shown to be effective in slowing down the ageing process, allowing people to maintain their health and vitality for longer.

Choosing between NR and NAD+: A consideration

Although there are no definitive studies or conclusive evidence to determine the superiority of the two, many ageing specialists, scientists, biotech companies and even organisations such as NASA and the US military have expressed a preference for NAD+ over nicotinamide riboside (NR). This preference is based on the perceived benefits of it, particularly its ability to prevent muscle wasting and to protect astronauts’ DNA from cosmic radiation.

In addition, NAD+ is more stable than NR. The latter is known for its instability in the bloodstream, often rapidly converting to vitamin B3 and breaking down into nicotinamide (NAM) before being absorbed by tissues. In contrast, it can be taken orally and assimilated without side effects. On the other hand, NR requires sublingual administration, which means that only specific products such as Renue by Science’s sublingual powder can effectively deliver NR in its most beneficial form.

Health And Wellness Benefits

Properly administered NAD+ supplements offer a wide range of potential health benefits. These include boosting energy metabolism, improving skin firmness, promoting brain and eye health, slowing the ageing process, increasing muscle function and responsiveness, preventing heart failure and improving organ performance.

In addition, these supplements could help reduce the risk of diabetes and obesity, and improve fertility. However, it is important to recognise that more research is needed to fully understand the full range of health benefits of NAD+ supplements. As a standard precaution, it is advisable to consult a healthcare professional before starting any new supplement routine.

Dosage And Intake

David Sinclair, a distinguished professor of genetics at Harvard Medical School, is a prominent proponent of NAD+ supplementation and reportedly takes 1000mg daily. The most recent and comprehensive human clinical trial to date has produced encouraging results, showing that daily intakes of 600mg and 900mg of NAD+ were significantly more effective than a lower dose of 300mg.

These results suggest that higher doses may be required to achieve optimal benefits. However, it is important to seek advice from a health professional before starting any new supplementation routine.

How to Choose The Perfect NAD+ Supplement?

When choosing the ideal NAD+ supplement, many elements need to be evaluated to ensure that you are purchasing a product that is both effective and trustworthy. A paramount consideration is authenticity. In order to avoid the risk of purchasing counterfeit or substandard products, it is advisable to conduct thorough research, including checking documents such as Certificates of Analysis (COA) or laboratory reports. These documents are crucial in confirming the authenticity and licensing of any NAD+ supplement under consideration.

Another important consideration is value for money, as a high price does not always mean superior quality in the NAD+ sector. It is wise to compare the prices of a few reputable supplements to avoid overpaying for inferior products. In addition, the accessibility of the supplement is a key factor, given the potential need for ongoing purchases. If the product is not easily accessible, replenishing your supply can become a challenge. Therefore, it is important to choose a supplement that is both readily available and easy to obtain.

Possible Side Effects

To date, there have been no documented adverse effects in humans associated with the use of these supplements. This is a promising outlook for individuals considering the use of NAD+ to slow the ageing process or improve their general health and well-being. However, it remains important to seek the advice of a health professional before starting any new supplement routine, as individual responses may vary.

Frequently Asked Questions

Conclusion

Although it is important to attend medical appointments regularly for check-ups and treatment, frequent visits can become monotonous, especially on days when the idea of leaving home seems less appealing. NAD+ supplements can be a useful substitute on these occasions.

However, it is important to recognise that NAD+ supplements are not a substitute for medical care from a doctor, as they only target specific health problems. It is therefore recommended that NAD+ supplements be used in conjunction with routine medical check-ups to achieve the best health outcomes.

Sources

1. National Center for Biotechnology Information. “ NAD+ homeostasis in human health and disease” PubMed, PMID 34041853. Read Article.
2. National Center for Biotechnology Information. “NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential” PubMed Central, PMC7539288. Read Article.
3. National Center for Biotechnology Information. “Nicotinamide Mononucleotide: Exploration of Diverse Therapeutic Applications of a Potential Molecule” PubMed Central, PMC6359187. Read Article.
4. ScienceDirect. “Homeostatic regulation of NAD(H) and NADP(H) in cells” ScienceDirect, S2352304223004294. Read Article.